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Indeed, the aerobic metabolic profile (available only with the 3 antioxidant molecules) was different from the anaerobic metabolic profile, which was confirmed by analysis of polar metabolites

However, the Clinical Study of Obesity and Intestinal Microbiota (ECOMI) trial showed that short-term CR (12 weeks) can lead to significant improvements in anxiety and depression scores in obese individuals only when combined with probiotic supplementation (63)

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Patients often notice: Reduced food obsession Less binge eating Better control around sweets 5

Unlike GLP-1 medications, metformin does not directly act on appetite-regulating hormones in your brain

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