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Interestingly, structure of an inhibitor of ACh esterase, acotiamide (brand name acofide), approved in Japan as a prokinetic motility drug against functional dyspepsia (216218), combines the two heterocycles, one of them thiazole, that may be considered as structural mimics of the thiazolium and aminopyrimidine heterocycles of thiamine

Vieth also pointed to a theoretical downside of the approach: Could it actually add more stress to patients' beta cells, and what would that mean for their functioning over the longer term

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Zhou Q., et al., n900) examined associations between Akkermansia abundance and metabolic markers