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doi: 10.1038/ismej.2014.99 221 RadAHAbbasalizadehSVazifekhahSAbbasalizadehFHassanalilouTBastaniPet al

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471 To enhance the delivery of neutrally charged oligonucleotides, Gait and Wood 472 developed a series of arginine-rich CPPs named [PNA/PMO]-internalized peptides (Pip), including Pip2a, Pip2b, Pip5e, and Pip6a

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Clinical trial data from the NEJM Phase 2 study showed that gastrointestinal events were predominantly mild to moderate, occurred primarily during dose escalation, and were partially mitigated by starting at 2mg rather than 4mg

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