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Body composition changes tend to follow over the subsequent months as growth hormone levels stabilise

The results of a preclinical study that examined the effect of SERT on body weight parameters in monkeys administered with SERT over an 18 mo period using a placebo-controlled, longitudinal, randomized study design showed that while the body weight and body fat composition of the placebo group increased, a decrease in body weight and fat composition was observed in the SERT treatment group[68]

Physical activity also helps maintain muscle mass during weight loss

In rodent models, blocking NNMT with 5-Amino-1MQ led to lower fat mass, more energy burn, and better insulin response all without cutting calories

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the proteins reside on the surface and seem to stabilize the structure