glp-1 before pregnancy Fertility: Why Weight Loss Alone Isn't the Answer​ GLP-1 medications like Ozempic, Wegovy

Younger people and those who lose weight more gradually tend to experience less loose skin

diet and exercise are still important factors for sustainable weight loss while taking a GLP-1 medication

Bariatric surgery patients tend to see about five times more weight loss than weekly injections of GLP-1s at the end of two years according to a new study

Diabetes Obes Metab 2017;19:15218.PubMed 14

Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (-aminoisobutyric acid (Aib)), but not recognized by the enzyme

Pratley RE, Aroda VR, Lingvay I, Ldemann J, Andreassen C, Navarria A et al (2018) Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial