Extensive investigations of G6PD from G6PD-deficient cells, mostly carried out before the sequence of G6PD was known, revealed that (1) enzyme activity, even when severely reduced (sometimes to less than 1% of normal), is never completely absent and (2) enzymic properties ( K m , K i , activity on substrate analogues, and thermostability, for example) are often different from those of the normal enzyme (i.e., G6PD deficiency is associated with qualitative abnormalities)
Some people experience mild symptoms, while others have more severe episodes
The mechanism appears to involve stimulation of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) activity, leading to accelerated triglyceride hydrolysis and increased free fatty acid release
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This is when youll experience the full effects of your current dose