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Severe side effects requiring discontinuation occur in fewer than 5% of cases, making semaglutide generally well-tolerated when dose increases are gradual and individualized

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[0018] In some particular embodiments of the present invention, the cleaving in the fragmental synthesis of the Lys 26 side chain in the preparation method is performed with 1-2% TFA/CH 2 Cl 2 (V/V) or 20% TFE/CH 2 Cl 2 (V/V)

However, it is important to maintain a measured perspective on what these findings mean in practical terms for patients and clinicians at this stage

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