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The SEMALEAN trial found lean mass declined then stabilised while handgrip strength improved by 4.5 kg and sarcopenic obesity prevalence fell from 49% to 33% over twelve months
To avoid a possible effect of food and water intake and physical activity, the meal plan and total daily fluid intake as well as physical activeness were kept constant during the study and the patients received a dietary advice with provided by a renal dietitian before the study commenced
The drugs have large molecules that make that very difficult, if not impossible, he notes
Its safety profile is generally consistent with other GLP-1-based therapies, with common side effects including nausea, diarrhea, and decreased appetite
Semaglutide, tirzepatide, and high dose dulaglutide have been deemed to have very high likelihood of achieving adequate blood sugar control, while other GLP-1s have been deemed highly likely