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International Journal of Epigenetics, 2025;5(1), 1.2 Ajjan RA, Weetman AP

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It is a structural component of glutathione and a co-factor of the antioxidant enzyme glutathione peroxidase

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Chemical Structure and Biosynthesis Although dopaminergic neurons represent less than 1% of cell subtypes in the brain, dopamine embodies approximately 80% of catecholamines in the CNS, though this figure is an estimate and may vary depending on measurement methods 1 Dopamine is a catecholamine that is primarily synthesized by dopaminergic neurons located in the substantia nigra and ventral tegmental area (VTA) of the brain, where this chemical messenger primarily functions as a neurotransmitter