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In the body, bilirubin is excreted as waste, but bilirubin can serve as an antioxidant molecule, and the bilirubin-biliverdin redox couple has direct antioxidant function [80]

In the epidermis, ROS induce oxidative DNA lesionsincluding 8-hydroxy-2-deoxyguanosine (8-OHdG) formation, mitochondrial DNA damage, and telomere attritionactivating the p53-p21 pathway and leading keratinocytes toward cell cycle arrest or apoptosis [183, 184]

Even indirect sunlight over a few hours can initiate photodegradation

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Naturally occurring peptides are essential for regulating cell regeneration, modulating the immune response, and facilitating hormone production, among other vital functions