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Endoplasmic reticulum stress: A key player in human disease
It is critical for maintaining the integrity of peptide bonds during experimental handling
Upon ligand binding, TLRs recruit adaptor proteins primarily MyD88 or TRIF which activate downstream kinases including IRAKs and TRAF6, leading to the stimulation of transcription factors NF-B, AP-1, and IRF family members [33]
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