Agents in this type 2 diabetes drug class have become popular weight loss medications and researchers are studying them for even more uses
For Maximum Weight Loss: Tirzepatide (22.5% average loss) Semaglutide (14.9% average loss) Distant third: Phentermine-topiramate (9.3% loss) For Best Value: Compounded semaglutide ($97 per pound lost) Compounded tirzepatide ($112 per pound lost) Others significantly worse For Most Patients: Compounded semaglutide or compounded tirzepatide provide the best combination of effectiveness, tolerability, and affordability
Zhang H, Zhou L, Yuen J, Birkner N, Leppert V, O'Day PA, et al
Lintsen AM, Braat DD, Habbema JD, et al
doi: 10.1038/nrd.2018.149 198 ShahzadKBockFAl-DabetMMGadiIKohliSNazirSet al
For others, maintaining smaller amounts may be a long-term strategy if higher doses are not well tolerated