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Yunpi Heluo decoction attenuates insulin resistance by regulating SIRT1-FoxO1 autophagy pathway in skeletal muscle of Zucker diabetic fatty rats

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The serine/glycine synthesis pathway branches from glycolysis via the glycolytic intermediate 3-phospho-glycerate, which can be converted into serine via three enzymatic reactions catalyzed by PHGDH, PSAT1, and PSPH, followed by the reversible interconversion of serine into glycine by SHMT1/2 (Figure 1)(2)

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Patch testing on the inner forearm before facial application is advisable when reintroducing