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It works by causing insulin release in response to high blood sugar (such as after a meal) and decreasing the amount of sugar your liver makes

Sci Rep 12(1):7415 Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, Qi L, Zhang M, Wang X, Cui T (2014) Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling

That low (and variable) uptake is why dosing conditions matter so much and why youll see careful instructions around taking it on an empty stomach with limited water and waiting before food/other meds

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May 2013;14(5):359-71

Ann Hematol 102 , 16291636 (2023)