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TESAMORELIN has been shown to significantly reduce visceral fat in patients with HIV-associated lipodystrophy, leading to improved body composition and metabolic health

The STEP 1 trial showed 14.9% weight loss with semaglutide plus lifestyle intervention

Animal Studies: Some animal studies have suggested that GLP-1 agonists could potentially lead to negative outcomes, such as delayed fetal development or other issues

Reviewer information Nature Reviews Endocrinology thanks M

The performance and financial cost of extended absence create motivation to explore off-label options despite regulatory and safety uncertainties

The most common reactions are temporary and localized to where the peptide is applied or injected