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A: GLP-1 agonists are medications that mimic the action of the naturally occurring GLP-1 hormone in the body

Control rats (group 1) are fed with standard diet, while the intervention rats are fed with iodine-free diet for 12 weeks to induce hypothyroidism (groups 2-4) which is continued for four more weeks to allow screening of hypothyroid status and L-Thyroxine-treatment

680,681,682 Small molecules targeting ferroptosis by regulating the ACSL4-LOX axis Lipid peroxidation is a hallmark of ferroptosis, and lipid-metabolizing enzymes such as ACSL4 and LOX contribute to ferroptosis

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Such oxidations are in direct competition with glutathione reductase and ABC transporters which usually maintain very low GSSG concentrations under physiological conditions 5,7,62,63,64