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Elevated intracellular iron levels facilitate the generation of ROS through Fenton chemistry, subsequently initiating lipid peroxidation reactions ( Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes

Subsequent analysis of morphine-induced constipation in VgluT2-Cre mice injected with AAV-DIO-shMOR-EGFP revealed that PVN Glu -specific MOR knockdown resulted in significantly higher fecal output and fecal water contents, as well as significantly higher transit rates and motility in small intestine of morphine-treated mice compared to that of corresponding AAV-DIO-EGFP control animals (Fig

the Special Scientific Research Project of the Sichuan Provincial Administration of Traditional Chinese Medicine (Grant No

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