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Instead, it is positioned closer to the outer side of the pocket, forming hydrogen bonds with several residues in the L2, L3, and L4 regions and being trapped at the pocket entrance

doi: 10.1016/j.xphs.2024.03.001 23 JangB

Ragu, S., Matos-Rodrigues, G., Lopez, B

The researchers also noted that melatonin was safe: regarding the incidence of adverse events, there was no significant difference between the melatonin and placebo groups

[46] However, clinical trials of oltipraz have failed to demonstrate clear therapeutic benefit and have reported significant toxicities, including neurotoxicity and gastrointestinal disturbances

Abbreviations: HTS, High-Throughput Screening