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ROS and chromatin ROS influence the activity of epigenetic modulators, such as histone deacetylases (HDACs) or DNA methyltransferases (DNMTs) with consequences that are evident in the expression of the target genes 38,39

VRK2 protects PC cells from ferroptosis by facilitating SLC7A11 trafficking Since SLC7A11-mediated cystine uptake and subsequent biosynthesis of GSH detoxifies phospholipid peroxidation and protects cells from ferroptosis [26], we speculated that VRK2-deficient PC cells, vulnerable to GSH inhibition is associated with ferroptosis

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Los tratamientos, incluido el danuglipron de Pfizer, pertenecen a una clase de frmacos que imitan la hormona intestinal pptido similar al glucagn tipo 1 (GLP-1), que acta suprimiendo el apetito y se desarroll inicialmente para tratar la diabetes tipo 2