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After incubation, TNF was added to induce the formation of ROS ( Figure 5 and Supplementary Figure S6 )
While the tumors treated with PBS showed an exponential growth, the tumor of the animals treated with Ru(II)-OH, NP2, or NP4 showed a tumor growth inhibition effect
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Mechanism 2: Increased Follicle Enlargement Research published in the Journal of Investigative Dermatology found that GHK-Cu increased follicle size by approximately 46% in study models consistent with the known effect of vascular growth factors that GHK-Cu upregulates (VEGF in particular drives nutrient delivery to follicles)
Ideal temperature is 15-30C
Preclinical evidence shows the significance of microbial metabolites and immune signaling in driving these effects, and recent clinical studies further supports these findings (Touchefeu et al., 2014
