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IUBMB Life (2017) 69(6):42334

People on semaglutide may feel the effects of alcohol more strongly and may experience stomach upset from caffeine

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The most commonly reported side effects are mild and transient: injection site redness or minor bruising, transient fatigue in the first one to two weeks, and occasionally mild headache following the first few injections, a pattern sometimes attributed to the acute shift in cellular energy metabolism as AMPK pathways are upregulated [3]