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Treatment typically involves addressing the sinus issue, which may include decongestants or antibiotics if a bacterial infection is present

Additionally, because people who use kratom may co-use other substances that can impact sleep and pain, such as caffeine, cannabis, alcohol, and opioids (Smith, Panlilio, Feldman, et al., 2024), clinicians should assess for concurrent use, as combining these substances may increase adverse effects

The diagnosis is clinical, based on symptom patterns and the exclusion of other conditions

Endogenously inhibitors are classified into enzymatic and non-enzymatic antioxidants, whereas exogenous inhibitors are synthetically or naturally originated antioxidants

They may be used alongside diet and exercise programs to optimize results.

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