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At appropriate concentrations, this supports healthy remodeling

However, the nuclear pore would not be expected to impose a physical barrier to NAD diffusion between the two compartments (Knockenhauer and Schwartz 2016), as the selective depletion of NMNAT2 or NMNAT1 limits NAD availability only in the cytosol or only in the nucleus (Ryu et al

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Dose and Frequency of Use Higher and more frequent dosing may saturate tissues and prolong the duration of activity