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Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

This is important for their treatment

Some studies have found that either Streptococci (73) or Alistipes (76) may be responsible for the IBS symptoms

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The gut immune system The commensal gut microbiota exerts a symbiotic relationship with the immune system by maintaining a non-inflammatory homeostasis