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Specifically, intestinal dysbiosis results in the loss of the gut barrier integrity that allows lipopolysaccharide (LPS) translocation from bacteria into circulation where LPS acts as a ligand-dependent toll-like receptor 4 (TLR4) stimulator initiating downstream signaling cascades amplifying the systemic inflammatory cascade (Longo et al., 2024)

Obesity genetics and cardiometabolic health: potential for risk prediction

Novo Nordisk data on file

Face, ears, eyelids, nose, and lips are categorically different site groupings

Mosah et al., 2015[36]

Psychological support addresses the emotional aspects of weight management and chronic disease