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Semaglutide and other GLP-1 compounds primarily regulate appetite signaling and nutrient absorption speed

Semaglutide | Comparing Benefits While injectable semaglutide is authorized for a more extensive spectrum of indications compared to dulaglutide, both peptides demonstrate similar benefits in subjects with and without T2D, as per the latest phase-3 trials

PMCID: PMC5112015

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Other interactions can increase side effects or make them more severe

The reasons for this difference are not fully understood, but it is generally believed that the blood glucose-lowering effect of semaglutide, leading to reduced urinary glucose loss, may result in relative energy retention, which may reduce weight loss [107]