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I have insulin resistance, am categorized as prediabetes, and have a family history of diabetes
Fatigue may occur because the body is adjusting to treatment, but it may also reflect under-eating, low protein intake, dehydration, electrolyte changes, rapid weight loss, poor sleep, constipation, low blood sugar, low blood pressure, or another medical issue
That means absorption can be delayed, bioavailability may be reduced, and effects can feel muted or inconsistent
How bioavailable or in other words, how absorbable a vitamin is is often influenced by factors, like age, genetics, and a persons digestive system ( For example, people with conditions affecting the digestive system might not benefit from liquid, gummy, or pill forms of vitamin B12
Storage and stability data are less well-established
DOI: 10.1186/s12876-017-0652-3 Kerksick C, et al
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