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The PD-L1/PD-1 interaction inhibits critical T cell signaling pathways (e.g., PI3K/AKT/mTOR), ultimately leading to exhaustion and apoptosis of the T cells, creating an immunosuppressive shield for tumors (88, 89)

At higher CBD doses (150mg+), physician awareness is appropriate

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Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patients outcome

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