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The observed metabolic-research differences between the two compounds are therefore not explainable by tirzepatide hits GLP-1 harder. They are explainable by the synergistic effect of dual-receptor engagement, where GIPR activation amplifies the downstream consequence of a lower-affinity GLP-1R hit
doi: 10.1038/s41392-024-01738-y 67 JesulolaEMicalosPBaguleyIJ
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