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There is no absolute contraindication to using GLP-1 receptor agonists in patients with Hashimoto's disease or established hypothyroidism

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This cardioprotective effect is thought to be due to several mechanisms, including improved endothelial function, reduced inflammation, and positive effects on lipid profiles

Its important to note that Bydureon BCise is prescribed with a balanced diet and exercise

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however, the addition of HCTZ to topiramate therapy may require a reduction in the topiramate dose