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PMID: 37023000

This understanding has led to the development of GLP-1 receptor agonists (such as semaglutide and liraglutide) and dual GIP/GLP-1 receptor agonists (such as tirzepatide) as pharmaceutical treatments

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However, patients should not self-treat severe or persistent constipation without medical advice, especially if they develop pain, bloating, vomiting, inability to pass stool or gas, or rectal bleeding

Effectiveness in Appetite Suppression GLP-1 drugs consistently reduce calorie intake by enhancing satiety and reducing hunger

However, EHR data showed smaller changes in BMI compared with baseline, with a median BMI % of 5.79%, which is significantly less than that reported in the self-report surveys (11.8%, P = 2.4 10 55 )