incretin hormone glp-1 A pathophysiological update of the incretins Targeting GLP-1, GIP & GCG

In their announcement about the retatrutide study, Eli Lilly medical experts said that about 11% of study volunteers who received the highest dose of the drug stopped taking it and dropped out of the study due to unpleasant side effects

Jason Brett, director mdico principal de Novo Nordisk en EE.UU., en una entrevista

Activation of murine pre-proglucagonproducing neurons reduces food intake and body weight

has acted as a speaker for Novo Nordisk and has received grants from Novo Nordisk, Novo Nordisk UK Research Foundation, Academy of Medical Sciences/ Diabetes UK and Health Education East Midlands

Since the insulinotropic activity of GLP-1 RAs is glucose- dependent, they do not pose a significant risk of hypoglycaemia

For example, GLP-1R agonism appears to facilitate new learning, potentially by modifying neural circuits involved in reward and adaptive behavior (Hanssen et al., 2023)