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Individual patient factors The safety and tolerability of this combination may vary depending on a patient's age, comorbidities, and other medications

a two-way ANOVA with repeated measures indicated that all time points for the I nmol dihexa group were different from the scopolamine group, which received vehicle (aCSF) instead of dihexa (***p .001)

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Together these modifications reduce IGFBP binding affinity by approximately 1,000-fold compared to native IGF-1 while preserving IGF-1 receptor (IGF1R) binding