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A 2025 Phase IIb trial found that intranasal glutathione improved symptoms in Parkinsons patients, with a 4-point reduction in disease severity scores

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Glutathione also reduces the release of inflammatory mediators and is associated with mitochondrial function and cellular longevity in aging studies

91 However, available experimental evidence suggests that NO is a double-edged sword when used to manage tumor diseases

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These findings support the theory that high-fat diets (potentially causing insulin resistance and T2DM) hinder mitochondrial biogenesis, which could clarify the development of anomalous myocardial performance in cases of obesity, insulin resistance, and fully developed diabetes [153]