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individuals with pre-existing retinopathy should be aware of this risk [28] [29] Pregnancy and breastfeeding incretin-based therapies should be avoided during pregnancy and breastfeeding unless within a supervised clinical trial, as safety data in these populations are absent Delayed gastric emptying a class effect of GLP-1 receptor agonists can reduce the absorption rate of concomitant oral medicines

GLP-1R signaling in the spinal cord has been suggested to account for the mild tachycardia caused by GLP-1R agonists, and may also be involved in the therapeutic effects of these drugs

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Its too early to compare the efficacy of newer generics with international brands, but if prescribed correctly under specialist care, these drugs could significantly reduce Indias overall disease burden, doctors said