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Patients should be advised to seek urgent medical attention if they experience severe abdominal pain, persistent vomiting, signs of pancreatitis, or visual changes

Overall, therefore, the main effects of GLP-1 are a reduction of fasting and postprandial blood glucose levels, lowering of body weight and protection from CVD, which are all therapeutic targets in type 2 diabetes (Fig

In migraine prophylaxis, preclinical models suggest that topiramate dampens cortical spreading depression, attenuates trigeminovascular calcitonin-gene-related-peptide release, and down-regulates central nociceptive transmitter traffic-mechanisms distinct from its antiepileptic activity but still rooted in excitatory-inhibitory balance

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