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Conversely, in another study involving chemotherapy-naive patients with malignant breast tumors, there was no statistical significance between the groups [(Ki-67, H3K9ac, H3K18ac, HDAC3, HDAC6 and p21 levels in all the three examined tissue types (benign, DCIS or IDC)] in patients who received 224 mg of BroccoMax daily for 2-4 weeks when compared to those who received placebo ( P= 0.003) and HDAC3 ( P= 0.044) levels in benign tissue (30)