restart semaglutide More than half of patients who stop weight-loss drugs within a year GLP-1 and the newer generation

None of them has undergone the kind of large-scale trials to establish safety and effectiveness that are required for FDA drug approvals

Follow-up plan: What monitoring, progress review, reorder guidance, or plan adjustments may matter if treatment proceeds

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Preferences influencing choice of additional medications may include blood pressure (BP) level, blood glucose level, potassium level, eGFR and kidney failure risk equation (KFRE) projected risk, weight management, and contraindications to medications or adverse effects (Table 2)

Metformin generally does not deliver the same weight loss results as GLP-1s, but for many patients, it can be a more affordable and accessible choice