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Immune System Effects IGF-1 signalling has documented effects on immune cell development and function

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In experimental models, MT1 is investigated for its ability to stimulate cyclic AMP (cAMP) production and to activate protein kinase A (PKA)-related pathways, which are involved in melanin production and cellular responses to UV-induced stress

These findings support the rationale for frequent, low-dose supplementation strategies in healthy individuals, while also emphasising the need for personalised approaches in those with malabsorption syndromes (Bor et al., 2010)