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B12 is essential for metabolic processes that convert food into energy

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It is worth mentioning that G6PD deficiency can downregulate another enzyme that requires NADPH: the thyroid NADPH oxidase necessary for the synthesis of triiodothyronine (T3) [129], whose lower levels could increase cardiovascular risk [130]

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Classically, this effect is attributed to the fact that the phosphate form of selenium, which is essential for some steps of the gene transcription for Se-GSH-Px synthesis, would be more readily available from selenite than from selenomethionine (Yasumoto et al., 1979