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53 In both Phase 1a and 1b trials, it has been established that orforglipron does not have food or water administration restrictions and may provide a safe and effective oral treatment option for patients with T2D and other indications

doi: 10.1016/S0021-9258(18)67324-7 23 HolstJJOrskovCNielsenOVSchwartzTW

This challenge is why some scientists question whether oral GLP-1 drugs can be as potent as injectables, Cavender says

The goal is for it to reduce what you eat later, not add to your total intake

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By influencing these physiological processes, GLP-1 agonists help reduce hunger and promote a feeling of fullness, thereby assisting in weight loss efforts