The necrotic nucleus extends outward into a region with low oxygen concentrations, referred to as hypoxia
It also helps combat free radicals to down regulate inflammation that can lead to flu like symptoms such as headaches, congestion, and sore muscles
Liver 1992;12(5):341-343
Thus, metal concentrations that are high enough to be toxic may still be too low to deplete cytosolic glutathione pools to a significant extent on a stoichiometric basis
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