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Napit R, Gurung A, Poudel A, Chaudhary A, Manandhar P, Sharma AN, et al

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(1998) showed no significant cortisol or ACTH elevation even at 200 times the effective GH-releasing dose

In an in vitro model of pancreatic islet INS-1 cells in PA-treated rats, SENDs increase mRNA expression of GPX1, enhance the level of Parkin/PINK1-mediated mitophagy, downregulate GRP78, PERK, eIF-2, and CHOP expression, and inhibited ERS and apoptosis, thereby maintaining the numerical and functional stability of pancreatic islet cells ( Activation of mitophagy alleviates insulin resistance and OS and improves T2DM

It has even been found to act as an antioxidant to other antioxidants as it can maximize the activity of Vitamin C and Vitamin E