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In septic mice, semaglutide attenuated sickness behavior, hypothermia, systemic inflammation, and lung injury through the downregulation of pro-inflammatory cytokines (TNF- , IL-1, IL-6, CXCL1), suppression of neutrophil infiltration, and decreased expression of genes associated with tissue remodeling and inflammation (Mmp9, Timp1, Ly6g)

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Barbieri RL, Smith S, Ryan KJ

However, there were only eight randomised controlled trials that specifically compared carnitine(s) to placebo or no treatment and study outcomes had high heterogeneity and were derived from low-quality evidence (Table 1)

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