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However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10
It calculates orbital interactions and predicts binding energies that mirror experimental findings
Interestingly, -tocopherol levels were not independently associated with Braak staging or neuritic plaque (NP) counts [9,12], indicating that its role may be more significant in early disease stages rather than in the progression of widespread neurodegeneration