This hypothesis derives from the fact that drugs, including phenylcyclohexylpiperidine (PCP), cause schizophrenia-like psychotic symptoms in humans by blocking the function of the NMDA receptor, and that such psychotic symptoms are difficult to diagnostically distinguish from schizophrenia ( Previous studies on schizophrenia has predominantly concentrated on dopaminergic and glutamatergic neurotransmitters
GPx activity may have influenced the formation of a smaller amount of superoxide anion radicals in yeast cells, which are primarily removed by other enzymes
Genetic mutations that decrease WFS1 are linked to depression, psychiatric disorders, and suicide risk.[ref][ref][ref] This is just the tip of the iceberg in terms of genes that can impact mitochondrial function
When these redox circuits are disrupted, critical redox active Cys sites become oxidized and protein functions are perturbed
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