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Extreme calorie restriction can also backfire because the body may shift into a starvation response that slows metabolism and holds onto fat stores

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240,241,242 Early studies on ASD-associated DNA methylation focused on several candidate genes, such as MECP2 , glutamate decarboxylase 65 ( GAD65 ), reelin ( RELN ), oxytocin receptor ( OXTR ), SHANK3 and UBE3A