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Recent post hoc and exploratory subgroup analyses of trials with the GLP-1RAs liraglutide and dulaglutide and the SGLT-2is empagliflozin and dapagliflozin have examined this and have suggested that the CV benefits of these agents are observed independent of background metformin use [10,11,12,13]

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Baseline health Where your health stands at the beginning of treatment matters

Any other effect can be considered as a pleiotropic, off-target effect, or in the case of unwanted actions, adverse effects ( Figure 1 )

In addition to that, the density of cortical stromal cells was markedly decreased, and vacuolated areas without stromal cells were detected between the atretic follicles