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Due to their inhibitory effects on T cell activation and function, DPP-4 inhibitors (DPP-4i) have been successfully evaluated in vivo as immunosuppressive therapies using animal models of rheumatoid arthritis (RA), multiple sclerosis (MS), and transplantation

Huang B, Wu P, Popov KM & Harris R (2003): Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney

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Usui R, Yabe D, Kuwata H, Murotani K, Kurose T, Seino Y