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Melanotan-1 (afamelanotide) is a selective MC1R agonist, while Melanotan-2 binds MC1R, MC3R, MC4R, and MC5R producing broader melanocortin receptor activity that includes appetite suppression, increased libido, and higher nausea incidence

They work through different biological pathways, address different aspects of ageing, and for most people the question isn't which one to choose - it's how to use both intelligently

This synthetic peptide amplifies your body's natural growth hormone production through mechanisms that differ fundamentally from direct GH injection

This is where supplementation can be beneficial

Diabetes Care 30 , 18621864 (2007)

MT2 is best known for its role in stimulating melanogenesis, the natural process through which the body produces melanin, the pigment that determines the color of our skin, hair, and eyes